GMC Phenomap

Phenomap legend:
New phenotype:	New phenotype:	Additional phenotype:	Additional phenotype:	Confirmed phenotype:	Confirmed phenotype:	Subtle phenotype:	Subtle phenotype:	No phenotype:	No phenotype:	Not analyzed:		Report:	Report

Mutant line	Symbol MGI ID	Gene symbol Gene name	B e h a v i o u r	D y s m o r p h o l o g y	N e u r o l o g y	E y e	C l i n i c a l c h e m i s t r y	I m m u n o l o g y	A l l e r g y	S t e r o i d	N o c i c e p t i o n	C a r d i o v a s c u l a r	L u n g f u n c t i o n	E x p r e s s i o n	M e t a b o l i s m	P a t h o l o g y	R e p o r t
DNaseX	Dnase1l1^tm1Dkfz MGI:4430191	Dnase1l1 deoxyribonuclease 1-like 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: New phenotype Phenotype description: muscular/coordination deficit	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Heart, muscle analyzed. Gene regulation identified in both organs	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: increased body weight	Pathology Screen Phenotype: No phenotype Phenotype description: -	Report
NADHo		Aifm2 apoptosis-inducing factor, mitochondrion-associated 2	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: Subtle phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Not analyzed Phenotype description: n/a	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: Not analyzed Phenotype description: not tested	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
NCAM	Ncam1^tm1Cgn MGI:1857222	Ncam1 neural cell adhesion molecule 1	Behavioral Screen Phenotype: Additional phenotype Phenotype description: increased exploratory activity	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition (males).	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related difference	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: brain analyzed. Only two regulated gene found	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight, hypotherm (after fasting)	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
DKK3	Dkk3^tm1Cni MGI:3621929	Dkk3 dickkopf homolog 3 (Xenopus laevis)	Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Clinical chemistry: Subtle changes of unclear relevance. Hematology: Hypochromic, macrocytic erythrocytes, increased hematocrit	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: New phenotype Phenotype description: Increased ventilation	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
DLG3	Gnl3^{Gt(W062C05)Wrst} MGI:4123403	Gnl3 Guanine nucleotide-binding protein-like 3	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: No differences detected.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
MAG	Mag^tm1Mtg MGI:2384092	Mag myelin associated glycoprotein	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition in males. Hearing loss. Cramping, when hung by tail.	Neurological Screen Phenotype: New phenotype Phenotype description: tremor, abnormal gait	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia (males)	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: New phenotype Phenotype description: disturbances in the central respiratory control ;	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: brain analyzed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Miz1	Pias2^{Gt(pT1Betageo)1Ruiz} MGI:2678428	Pias2 protein inhibitor of activated STAT 2	Behavioral Screen Phenotype: New phenotype Phenotype description: altered social and exploratory behavior, middle ear phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: New phenotype Phenotype description: abnormal posture	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting different cellular subsets	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: New phenotype Phenotype description: reduced ventilatory drive;	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: testis analyzed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: Confirmed phenotype Phenotype description: n/a	Report
DMBT1	Dmbt1^tm1Janm MGI:3771872	Dmbt1 deleted in malignant brain tumors 1	Behavioral Screen Phenotype: No phenotype Phenotype description: Subtle changes males more caution	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
DEA3	Tmc1^Bth MGI:2177263	Tmc1 transmembrane channel-like gene family 1	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: increased caution (males), increased angular velocity (females)	Dysmorphology, Bone and Cartilage Screen Phenotype: Confirmed phenotype Phenotype description: Deafness. Changes in body composition (females)	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Well-pronounced B cell phenotype	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: New phenotype Phenotype description: differences in breathing pattern might be related to the different activity behavior	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: increased body weight	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Dll1-129	Dll1^tm1Gos	Dll1 delta-like 1 (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity (females)	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition.	Neurological Screen Phenotype: New phenotype Phenotype description: hyperactivity	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related difference	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Thymus, liver, spleen, brain analyzed. Differential gene expression in all organs.	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight and body fat	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
ABE1			Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition. Head tossing (females).	Neurological Screen Phenotype: Additional phenotype Phenotype description: tremor	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: brain analyzed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
ABE2	Jag1^Htu MGI:2386949	Jag1 jagged 1	Behavioral Screen Phenotype: New phenotype Phenotype description: hyperactivity, abnormal social behavior	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition. Head shaking.	Neurological Screen Phenotype: Additional phenotype Phenotype description: reduced grip strength, abnormal motor coordination/ balance	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Increased AP and AMY activity indicate changes in pancreas function or liver function or bone metabolism. Changes in energy metabolism related parameters are likely to be due to hyperactivity. Indications of changes in iron metabolism or transferrin synthesis in the liver.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hyperalgesia	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Liver, spleen, thymus, brain, muscle analyzed. Several gene regulated in liver and spleen. No gene regulation in thymus, brain and muscle.	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: Subtle phenotype Phenotype description: tendency to develop inflammatory pseudotumors	Report
Trm1	1190005F20^{RikGt(W027A02)Wrst} MGI:3702935	Trm1 tRNA methionine initiator 1	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory behaviour	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Bone mineral density and body weight reduced in females.	Neurological Screen Phenotype: New phenotype Phenotype description: abnormal motor coordination/ balance	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: New phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: brain analyzed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: Subtle phenotype Phenotype description: tendency of increased immunoreactivity	Report
Eyl	Pitx3^eyl MGI:4429408	Pitx3 paired-like homeodomain transcription factor 3	Behavioral Screen Phenotype: New phenotype Phenotype description: altered emotional behavior	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition (females).	Neurological Screen Phenotype: Additional phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: Confirmed phenotype Phenotype description: Severe microphthalmia	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Differences in fat metabolism and liver and/or pancreas function. Indications of effects on muscle function.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: New phenotype Phenotype description: altered spontaneous breathing pattern with more frequent	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Liver analyzed	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: reduced body weight, hypotherm (after fasting)	Pathology Screen Phenotype: Additional phenotype Phenotype description: Microphthalmia (females), BW reduced, increased extramedullary hematopoiesis (males)	Report
Ptdsr	Jmjd6^tm1.1Gbf MGI:3606752	Jmjd6 jumonji domain containing 6	Behavioral Screen Phenotype: New phenotype Phenotype description: reduced anxiety	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance. Hints on kidney dysfunction.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Thymus, brain, liver, spleen, heart analyzed. Gene regulation in thymus only.	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: n/a	Pathology Screen Phenotype: Subtle phenotype Phenotype description: Microphthalmia (not significant)	Report
Vimentin	Vim^tm2Cba MGI:1931879	Vim vimentin	Behavioral Screen Phenotype: New phenotype Phenotype description: abnormal social behavior (males)	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Bone mineral content, body weight and fat mass reduced in females.	Neurological Screen Phenotype: Additional phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Uric acid and white blood cell count increased. Indications of changes in kidney function and/or electrolyte homeostasis. Glucose level reduced in females	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia (males), Hyperalgesia (females)	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: respiratory rate differences failed to be statistically significant.; In view of the observed pulmonary infection interpretation of the results is hardly possible. ;	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Spleen analyzed. Regulated gene asscociated with immune response and apoptosis	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: n/a	Pathology Screen Phenotype: New phenotype Phenotype description: increased T-cells in the PALS, reduced GFAP expression in the cerebellum	Report
mPtpg	Nipal3^tm1Pebu MGI:4360699	Nipal3 NIPA-like domain containing 3	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploration	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance in males only.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: New phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: New phenotype Phenotype description: elevated ventilation detected during rest and activity is primarily related to the higher tidal volume used by mutant males	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Brain analyzed	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
PK			Behavioral Screen Phenotype: Not analyzed Phenotype description: n/a	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition	Neurological Screen Phenotype: Subtle phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Only changes of unclear relevance, mostly limited to one sex. There seems to be an influence on erytropoiesis but without pathological effects.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting both the cellular subsets distribution and immunoglobulin levels in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Spleen, liver analyzed. Regulated gene in spleen accociated with immune response. No gene regulation in liver.	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: New phenotype Phenotype description: enlarged marginal zone in the spleen	Report
TP53	Trp53inp1^tm1Acar MGI:3700974	Trp53inp1 transformation related protein 53 inducible nuclear protein 1	Behavioral Screen Phenotype: New phenotype Phenotype description: altered locomotion	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: Subtle phenotype Phenotype description: n/a	Eye Screen Phenotype: New phenotype Phenotype description: intraretinal microflecks; disturbances in retinal lamination	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Complex phenotype affecting the cellular subsets distribution in the periphery	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: -	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences (females)	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Spleen, thymus analyzed	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: hypotherm (after fasting)	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Arl4	Arl4a^tm1Asch MGI:2181269	Arl4a ADP-ribosylation factor-like 4A	Behavioral Screen Phenotype: New phenotype Phenotype description: altered arousal	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Small changes in bone mineral density and body weight in males.	Neurological Screen Phenotype: Subtle phenotype Phenotype description: n/a	Eye Screen Phenotype: Subtle phenotype Phenotype description: Slightly increased axial eye lengths in males	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hyperalgesia	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypertension	Lung Function Screen Phenotype: Not analyzed Phenotype description: n/a	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: n/a	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: reduced body weight, hypotherm (ad libitum)	Pathology Screen Phenotype: Subtle phenotype Phenotype description: reduced testis weight*	Report
FoxP2	Foxp2^tm1Woen MGI:3851106	Foxp2 forkhead box P2	Behavioral Screen Phenotype: New phenotype Phenotype description: Hypoactivity, increased caution	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: New phenotype Phenotype description: hypoactivity	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: No differences detected.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: n/a	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: n/a	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences;	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Brain analyzed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Glut8		Slc2a8 solute carrier family 2, (facilitated glucose transporter), member 8	Behavioral Screen Phenotype: New phenotype Phenotype description: increased emotional reactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: New phenotype Phenotype description: red grip strength (males)	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: n/a	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: minor changes	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Muscle, testis, liver analyzed. Regulated genes in muscle and liver associated with significantly expressed genes are associated with functions in fatty acid and glucose metabolism. No gene regulation in testis.	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: energy balance	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
M076C04	Nkain4^{Gt(M076C04)Vmel} MGI:4413343	Nkain4 Na+/K+ transporting ATPase interacting 4	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance regarding locomotion and behaviour towards the board	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: New phenotype Phenotype description: nuclear or posteriorpolar opacity	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: Finding of unclear relevance. CD44 is also expressed on activated B cells	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: n/a	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: n/a	Lung Function Screen Phenotype: No phenotype Phenotype description: no differences	Molecular Phenotyping Screen Phenotype: No phenotype Phenotype description: Brain analyzed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Eps8	Eps8^tm1Ppdf MGI:3693626	Eps8 epidermal growth factor receptor pathway substrate 8	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory pattern	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Deafness.	Neurological Screen Phenotype: New phenotype Phenotype description: Hypoactivity	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Subtle changes of unclear relevance. Hyperkalemia, which might influence pulse rate.Indications of effects on energy metabolism.	Immunology Screen Phenotype: No phenotype Phenotype description: Expression of �??homing markers�??, possibly due to �??activation�??	Allergy Screen Phenotype: No phenotype Phenotype description: no	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Bradycardia	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Subtitle Changes; body weight related differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: White fat, brown fat, liver analyzed	Energy Metabolism Screen Phenotype: Confirmed phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Dll1-C3H	Dll1^tm1Gos MGI:1861919	Dll1 delta-like 1 (Drosophila)	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: mild alterations in horizontal activity/exploration	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition.	Neurological Screen Phenotype: Subtle phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Indication of an effect on energy metabolism and hematopoiesis.	Immunology Screen Phenotype: New phenotype Phenotype description: alterations in the memory T cell compartment. Normally, CD62L expression is high on na�ve Tcells and central memory cells.	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: n/a	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypotension (males), Bradycardia,	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body weight related differences	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Thymus, liver, spleen, brain analyzed	Energy Metabolism Screen Phenotype: Confirmed phenotype Phenotype description: n/a	Pathology Screen Phenotype: Confirmed phenotype Phenotype description: n/a	Report
sighted C3H	Pde6b+ C3H.C-Pde6b+/H	Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory pattern	Dysmorphology, Bone and Cartilage Screen Phenotype: New phenotype Phenotype description: Changes in bone homeostasis and body composition (secondary effect due to clear differences in body parameters)	Neurological Screen Phenotype: Subtle phenotype Phenotype description: n/a	Eye Screen Phenotype: New phenotype Phenotype description: Increased axial length in C3H.Pde6b+; no b �??wave response in C3H.Pde6b+	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Reduced percentage of CD8+ T cells and h�herer percentage of granulocytes; sex: Male: Reduced percentage of CD4+ T cells, Increased IgG2b plasma level (only males)	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: not analysed	Nociceptive Screen Phenotype: New phenotype Phenotype description: Hypoalgesia (females)	Cardiovascular Screen Phenotype: New phenotype Phenotype description: C3H.Pde6b+ mutant mice carry a functional BalbC allele of the gene of interest, while the control C3H/HeH mice represent a natural null allele of Pde6b. Among the commonly used lab strains we find that these C3H mice with retinal degeneration exhibit relatively high values for QT interval and QTc.	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Major phenotype unlikely, mainly body weight related differences.	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Brain, heart analyzed	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: reduced body weight,	Pathology Screen Phenotype: No phenotype Phenotype description: -	Report
Eya3	Eya3^{Gt(W096D02)Wrst} MGI:3834107	Eya3 eyes absent 3 homolog (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: altered exploratory pattern	Dysmorphology, Bone and Cartilage Screen Phenotype: Subtle phenotype Phenotype description: Bone mineral content, body length and body weight reduced in males.	Neurological Screen Phenotype: New phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: Subtle phenotype Phenotype description: Difference in normalised (for body length) axial eye length.	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: not analysed	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Changes in conduction and voltage properties	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Decreased tidal volume	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: muscle, heart, brain analyzed	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: New phenotype Phenotype description: -	Report
GSK3 beta		Gsk3b glycogen synthase kinase 3 beta	Behavioral Screen Phenotype: New phenotype Phenotype description: Reduced velocities, eventually increased anxiety	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition	Neurological Screen Phenotype: New phenotype Phenotype description: reduced grip strength	Eye Screen Phenotype: Subtle phenotype Phenotype description: Slightly reduced axial eye lengths	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Changes in energy metabolism related parameters indicate effects on energy balance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: sex: Male: only male: increased percentage of B cells, reduced percentage of Granulocytes, slightly increased percentage of gdT cells	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly decreased testosterone concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: Not tested	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Changes in conduction properties, hypotension, bradycardia	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Body mass related differences; physiologically not relevant	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Brain, muscle analyzed	Energy Metabolism Screen Phenotype: Additional phenotype Phenotype description: n/a	Pathology Screen Phenotype: New phenotype Phenotype description: cerebrum	Report
FoxP2-KO	Foxp2^tm2.2Woen MGI:3851108	Foxp2 forkhead box P2	Behavioral Screen Phenotype: Additional phenotype Phenotype description: Confirmed hypoactivity, reduced neophobia	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: Confirmed phenotype Phenotype description: abnormal motor coordination/ balance also in heterozygous animals	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: Subtle phenotype Phenotype description: sex: Male: increased percentage CD62L-expressing CD8+ T cells (only males ); sex: Female: increased percentage of T cells (only females).	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: No phenotype Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Subtle phenotype Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: No differences of phjysiological relevance	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: -	Report
C1orf37		Tmem183a transmembrane protein 183A	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: mild hyperactivity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: No phenotype Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: n/a	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: Minor changes	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: increased energy consumption	Pathology Screen Phenotype: No phenotype Phenotype description: -	Report
GSK3 alpha		Gsk3a glycogen synthase kinase 3 alpha	Behavioral Screen Phenotype: New phenotype Phenotype description: increased anxiety	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition in males	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: New phenotype Phenotype description: sex: Male: Increased axial eye length in males	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Results indicate effects on hematopoiesis resulting in macrocytosis, and changes in energy metabolism.	Immunology Screen Phenotype: New phenotype Phenotype description: sex: Female: Differences in percentage between T and B cells: (only females).	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Female: mutant mice have decreased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: Not tested	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypotension, Bradycardia	Lung Function Screen Phenotype: Not analyzed Phenotype description: n/a	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Brain, muscle analyzed.Regulated gene in muscle are associated with blood circulation and gas exchange and protein phosphorylation. No gene regulation in brain	Energy Metabolism Screen Phenotype: Additional phenotype Phenotype description: n/a	Pathology Screen Phenotype: New phenotype Phenotype description: -	Report
Dll1-C413Y	Dll1^C413Y	Dll1 delta-like 1 (Drosophila)	Behavioral Screen Phenotype: New phenotype Phenotype description: Hyperactivity; sex: female: enhanced prepulse inhibition	Dysmorphology, Bone and Cartilage Screen Phenotype: Additional phenotype Phenotype description: Changes in bone homeostasis and body composition	Neurological Screen Phenotype: New phenotype Phenotype description: Hyperactivity	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Plasma lipid and urea values suggest changes in energy metabolism.	Immunology Screen Phenotype: New phenotype Phenotype description: sex: Male: In males we foand a reduced frequency of ICAM-1 expresssing cells and slightly higher levels of IgG2a and IgG2b	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: No phenotype Phenotype description: -	Nociceptive Screen Phenotype: No phenotype Phenotype description: no phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Hypertension	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: sex: Female: Only female mice showed slight differences; physiologically not relevant	Molecular Phenotyping Screen Phenotype: New phenotype Phenotype description: Liver, spleen, brain and thymus analysed. Gene differentially expressed in spleen associated with cell proliferation, signaling and embryogenesis. No gene regulation found in liver, thymus, and brain.	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: n/a	Pathology Screen Phenotype: New phenotype Phenotype description: Possible neoformation of pancreatic islet. Not confirmed by secondary screen (ICH)	Report
Irf1	Irf1^{tm1a(EUCOMM)Wtsi} MGI:4431834	interferon regulatory factor 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Results indicate effects on fat and glucose metabolism, moderate macrocytosis and reduced ALP and amylase activity in mutants.	Immunology Screen Phenotype: Confirmed phenotype Phenotype description: Described phenotype of a low freq. of CD8+ Tcells and of inverse trend in CD4+ Tcells was confirmed.	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly increased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: n/a	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: -	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Setdb1	Setdb1^{tm1a(EUCOMM)Wtsi} MGI:4432424	SET domain, bifurcated 1	Behavioral Screen Phenotype: New phenotype Phenotype description: Prepulse inhibition deficit; sex: Female: hyperactivity (females)	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: No phenotype Phenotype description: No significant differences detected.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: New phenotype Phenotype description: Mutant mice have low levels of IgE	Steroid Screen Phenotype: No phenotype Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: sex: Male: Tachycardia, increased heart weight in males	Lung Function Screen Phenotype: Subtle phenotype Phenotype description: slight differences of minor physiological relevance	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: No phenotype Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Aldh2	Aldh2^{tm1a(EUCOMM)Wtsi}	Aldh2 aldehyde dehydrogenase 2, mitochondrial	Behavioral Screen Phenotype: New phenotype Phenotype description: Sex-specific alterations in activity	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Decreased triglyceride levels and mild macrocytosis in mutant animals.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly decreased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Tachycardia, increased heart weight	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: Not analyzed Phenotype description: -	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Pml		Pml promyelocytic leukemia	Behavioral Screen Phenotype: Subtle phenotype Phenotype description: subtle changes of unclear relevance	Dysmorphology, Bone and Cartilage Screen Phenotype: Not analyzed Phenotype description: n/a	Neurological Screen Phenotype: New phenotype Phenotype description: Hyperactivity	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Differences compared to wildtype controls were foand concerning the freq. of CD19+/CD5+ cells, and the proportions of T cell subsets. Especially, T cells from Plm mutant mice showed a high expression of CD62L+ (CD4+ and CD8+), a high expression of CD44 (	Allergy Screen Phenotype: Not analyzed Phenotype description: No data for this strain (lack of blood sample)	Steroid Screen Phenotype: No phenotype Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: Not analyzed Phenotype description: n/a	Lung Function Screen Phenotype: Not analyzed Phenotype description: n/a	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: Not analyzed Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Dusp4	Dusp4^{tm1a(EUCOMM)Wtsi}	Dusp4 dual specificity phosphatase 4	Behavioral Screen Phenotype: New phenotype Phenotype description: sex: Femanle: Reduced anxiety (females)	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: No phenotype Phenotype description: n/a	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Not analyzed Phenotype description: still in analysis	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Bradycardia	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: Not analyzed Phenotype description: n/a	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
nos2	Nos2^{tm1a(EUCOMM)Wtsi}	Nos2 nitric oxide synthase 2, inducible	Behavioral Screen Phenotype: New phenotype Phenotype description: Prepulse inhibition deficit only in females	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: No phenotype Phenotype description: n/a	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: New phenotype Phenotype description: Many mild differences of unclear relevance. Fat metabolism, kidney function and liver function and integrity might be affected.	Immunology Screen Phenotype: New phenotype Phenotype description: Nos-2 mutant mice showed a slightly higher freq. of T cells and NK cells and a lower freq. of Bcells.	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: Subtle phenotype Phenotype description: Male: mutant mice have slightly increased DHEA concentrations	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: No phenotype Phenotype description: n/a	Lung Function Screen Phenotype: No phenotype Phenotype description: no genotype-related differences	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: Hypermetabolism	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Hdac1	Hdac1^{tm1a(EUCOMM)Wtsi}	Hdac1 histone deacetylase 1	Behavioral Screen Phenotype: No phenotype Phenotype description: no phenotype	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: New phenotype Phenotype description: More excitation/Alertness (Tail elevation)	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: Lower levels of IgM	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: No phenotype Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: No phenotype	Cardiovascular Screen Phenotype: New phenotype Phenotype description: Bradycardia	Lung Function Screen Phenotype: No phenotype Phenotype description: differences ofphysiological minor relevance; specific TV and specific MV are comparable	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: New phenotype Phenotype description: Hypermetabolism, fat mass reduced	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report
Plxnb2	Plxnb2^{tm1a(EUCOMM)Wtsi}	Plxnb2 plexin B2	Behavioral Screen Phenotype: New phenotype Phenotype description: Increased prepulse inhibition only in females	Dysmorphology, Bone and Cartilage Screen Phenotype: No phenotype Phenotype description: n/a	Neurological Screen Phenotype: New phenotype Phenotype description: abnormal motor coordination/ balance	Eye Screen Phenotype: No phenotype Phenotype description: n/a	Clinical Chemical Screen Phenotype: Subtle phenotype Phenotype description: Subtle changes of unclear relevance.	Immunology Screen Phenotype: New phenotype Phenotype description: sex: Female: Higher freq. of B cells, lower freq. of T cells and NK cells	Allergy Screen Phenotype: No phenotype Phenotype description: n/a	Steroid Screen Phenotype: No phenotype Phenotype description: n/a	Nociceptive Screen Phenotype: No phenotype Phenotype description: Not tested-	Cardiovascular Screen Phenotype: No phenotype Phenotype description: n/a	Lung Function Screen Phenotype: Not analyzed Phenotype description: n/a	Molecular Phenotyping Screen Phenotype: Not analyzed Phenotype description: No organs selected for expression profiling analysis	Energy Metabolism Screen Phenotype: Subtle phenotype Phenotype description: -	Pathology Screen Phenotype: No phenotype Phenotype description: n/a	Report