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Helmholtz Zentrum München- German Research Center for Environmental Health
Institute of Experimental Genetics
85764 Neuherberg |
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For functional testing of the vascular system and detection of cardiac pathologies in Mutant Mouse Lines (MMLs) innovative techniques and miniaturized classical physiological procedures are applied to achieve a non-invasive analysis of cardiovascular structure and function.
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| Primary Screen |
- Blood pressure : The non-invasive analysis in conscious animals measures the peripheral blood pressure in the caudal
artery of the mice with a tail-cuff inflation system. Systolic, diastolic and mean arterial pressure is determined over a 4-day period to comprise
the natural variability of the blood pressure.
- ECG: A 6-lead limb surface ECG measures the electrical activity, rate and rhythm of the heart beat, supplying
information about the conductive and myocardial properties.
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| Secondary Screen |
- High frequency ultrasound biomicroscopy: This innovative high resolution imaging enables in vivo assessment of structural and functional cardiovascular abnormalities within three different imaging modes:
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B-mode: provides a 2-dimensional picture of the anatomical structures such as ventricle size and wall thickness.
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M-mode: displays the motion of tissue structures as a function of time supplying information about contraction and pump capacity.
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Doppler mode: examines the blood flow velocity and direction for hemodynamic investigations or valve functional test.
Additional examinations are possible in cooperation with the members of the Cardio Vascular Disease Network and the Muenster Mouse Clinic
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PA Doppler
M-mode doppler
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