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MIM - Initiation mechanism for dendritic spines


Researchers from the University of Helsinki, ETH Zürich, Aix-Marseille and the German Mouse Clinic teamed up to investigate the initiation process of dendritic spines. They discovered that protein called MIM bends the plasma membrane to aid the formation of dendritic spines from the surface of the neuronal dendrite.

The discovery is important, as most of the neuronal connections, called synapses, are build to dendritic spines. In many central nervous system diseases, the dendritic spine density is altered.

"Understanding of the molecular mechanisms underlying the initiation process of dendritic spines enables us to manipulate their initiation rate and density. In future, this knowledge can be helpful in the development of therapeutic interventions for neurological diseases underlined by altered dendritic spine density, such as autism spectrum disorder, Schizophrenia or Alzheimer´s disease. Furthermore, this will help us to understand the molecular basis of learning, as new spines are readily initiated during learning," says project leader Pirta Hotulainen from the Neuroscience Center of the University of Helsinki.

This research has been collaboration between many distinct research groups combining cell biology to neuroscience. "No sole research group could have achieved such a comprehensive view of the dendritic spine initiation mechanism and show its importance for the brain function," says Pirta Hotulainen.

Fig. 1: Time frames of MIM and F-actin dynamics during initiation of dendritic spine. MIM initiates dendritic spines by coupling phosphoinositide-signaling, direct membrane bending and actin assembly together to ensure proper synaptogenesis.

Saarikangas et al., MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation. Developmental Cell (2015), http://dx.doi.org/10.1016/j.devcel.2015.04.014