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Increased E/A ratio alters liver metabolism

Source: GMC


The influence of the sex steroid hormones estrogens and androgens on metabolism is object of several studies. Estrogens are suggested to lower the risk of developing metabolic syndrome in both sexes. In males the estrogen-to-androgen ratio (E/A) is important for normal development, especially concerning epiphyseal closure, bone density and reproductive functions. In this study the effect of a higher E/A ratio in male mice was analysed. Mice overexpressing human aromatase (AROM+ mice) enzyme have a higher E/A ratio because cytochrome P450 aromatase (P450arom) converts androgens to estrogen.

The analysis of the transcriptome and proteome of AROM+ and wildtype mice revealed that liver metabolism is altered. Peroxisomal β-oxidation is increased while arachidonic acid metabolism is decreased. Consequently the plasma phospholipid profile is altered.

Anni P. Vehmas, Marion Adam, Teemu D. Laajala, Gabi Kastenmüller, Cornelia Prehn, Jan Rozman, Claes Ohlsson, Helmut Fuchs, Martin Hrabě de Angelis, Valérie Gailus-Durner, Laura L. Elo, Tero Aittokallio, Jerzy Adamski, Garry Corthals, Matti Poutanen, Leena Strauss: Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse. Journal of Proteomics 133 (2016) 66–75. dx.doi.org/10.1016/j.jprot.2015.12.009