German Mouse Clinic
German Mouse Clinic
Scientists have identified a network of genes that could play an important role in the development of metabolic diseases such as diabetes. The German Mouse Clinic, collaboration partners within the Helmholtz Center Munich and the International Mouse Phenotyping Consortium (IMPC) led the work that...
Paladin or Pald1 is a phosphatase-domain containing protein and was identified in two independent screens for novel regulators of angiogenesis and vascular function. In a collaboration with colleagues in Sweden, the German Mouse Clinic characterized the new Pald1−/− mouse model performing...
The International Mouse Phenotyping Consortium (IMPC) including the German Mouse Clinic, Helmholtz Zentrum München, succeeded in shedding light on more than 50 new hearing genes. The study was recently published in Nature Communications.The developmental and physiological complexity of the...
Efficient phenotyping is essential for the identification of relevant changes and phenotypes and for the reproducibility of scientific experiments. A number of automated tests have been developed to speed up data acquisition, to make the results more objective and replicable and to reduce the...
While it is recognized that maternal departures from the optimum of dietary methyl donor intake, such as folic acid, methionine or vitamine B12, can increase the risk for mental health issues and neurological disorders in offspring, it has not been explored whether paternal dietary methyl donor...
Phenotype your mouse model
- Systemic, comprehensive phenotyping in 14 different disease areas
- Customized primary phenotypic screening in specific areas of interest (e.g. behavior, neurology and neuropathology)
- Hypothesis-driven phenotypic analysis using environmental challenges
- Combining environmental challenges
- Systemic analysis of compounds and drugs
View results of mutant lines
View the results of mutant mouse lines in the GMC phenomap.
IMPC - Intl Mouse Phenotyping Consortium
View the status of IMPC lines and their phenotyping results.
How primary mouse phenotyping leads to novel insights for human health
Mouse phenotyping helps to better understand human diseases. Read more how systemic primary screening of mouse mutants uncovers unexpected new gene functions.