Four Opa1 isoforms are expressed in mice, which differ in the presence or absence of cleavage sites for Oma1 and for Yme1l. Mutations in the gene OPA1…

On April 29^th and 30^th, the second F2F CHARLIE Consortium meeting took place at Helmholtz Munich, organized by the German Mouse Clinic (GMC) as…

Congenital anomalies of the kidney and the urinary tract (CAKUT) are the predominant cause for chronic kidney disease below age 30 years and the main…

Genetic malformations often occur during early pregnancy and unraveling the genetic basis for the resulting disorder is challenging. Current…

A team of scientists at the Baylor College of Medicine, the Chinese University of Hong Kong, the German Mouse Clinic and collaborating institutions…