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GMC - German Mouse Clinic


German Mouse Clinic

GMC - German Mouse Clinic


German Mouse Clinic


Is CatWalk sufficient for locomotor analysis?

Efficient phenotyping is essential for the identification of relevant changes and phenotypes and for the reproducibility of scientific experiments. A number of automated tests have been developed to speed up data acquisition, to make the results more objective and replicable and to reduce the...


Paternal diet influences cognitive functions in offspring

While it is recognized that maternal departures from the optimum of dietary methyl donor intake, such as folic acid, methionine or vitamine B12, can increase the risk for mental health issues and neurological disorders in offspring, it has not been explored whether paternal dietary methyl donor...


Male or female? Disease progress depends on the sex

The international research consortium IMPC has shown that sex influences the prevalence, course and severity of the majority of common diseases and disorders. The German Mouse Clinic, Helmholtz Zentrum München, played an important role in this study, published in Nature Communications. The analyzed...


SRF and its role in acute stress response

The brain is the central organ that ensures immediate and long-term adaptions to stress. Acute stress (AS) and chronic stress (CS) induce several – and distinct – responses including body weight adaption, metabolic and cardiovascular changes, altered memory, learning, locomotor and exploratory...


Spermidine – cardioprotection and life span extension

Cardiovascular disease has reached epidemic proportions in the aging society and remains the worldwide leading cause of death. This publication shows that the natural spermidine protects the heart from age associated deteriorations and suggests a new and feasible strategy for the prevention of...

Phenotype your mouse model


  1. Systemic, comprehensive phenotyping in 14 different disease areas
  2. Customized primary phenotypic screening in specific areas of interest (e.g. behavior, neurology and neuropathology)


  1. Hypothesis-driven phenotypic analysis using environmental challenges
  2. Combining environmental challenges


  1. Systemic analysis of compounds and drugs

View results of mutant lines

View the results of mutant mouse lines in the GMC phenomap.

IMPC - Intl Mouse Phenotyping Consortium

View the status of IMPC lines and their phenotyping results.

How primary mouse phenotyping leads to novel insights for human health

Mouse phenotyping helps to better understand human diseases. Read more how systemic primary screening of mouse mutants uncovers unexpected new gene functions.

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The GMC Consortium

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