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GMC - German Mouse Clinic

GMC

German Mouse Clinic

GMC - German Mouse Clinic

GMC

German Mouse Clinic

07.09.2020

Is there an essential physiological role for the oncogenic neuronal inositol-1,4,5-trisphosphate 3-kinase?

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is the neuronal isoform of ITPKs and exhibits both actin bundling and InsP3kinase activity. In...

24.08.2020

METTL5 – a new human RNA methyltransferase that is involved in human diseases

An international team of researchers lead by Helmholtz Zentrum München uncovered the molecular mechanisms that link rRNA methylation to development...

10.03.2020

New link between iron deficiency in pancreatic cells and diabetes

The role for iron in the pathogenesis of diabetes is on debate. While the consequences of excess iron in β-cell function and survival are established,...

09.12.2019

Mouse Model mimics the most important features of rare methylmalonic aciduria

In a collaborative effort, scientists from the University of Zurich and the German Mouse Clinic investigated the potential of a new mouse model for...

24.09.2019

News regarding the claudin family member 12 and blood-brain barrier integrity

In a collaborative study, scientists from the University of Bern and the German Mouse Clinic investigated the impact of the claudin family member 12...

Phenotype your mouse model

GMC I: 

  1. Systemic, comprehensive phenotyping in 14 different disease areas
  2. Customized primary phenotypic screening in specific areas of interest (e.g. behavior, neurology and neuropathology)

GMC II: 

  1. Hypothesis-driven phenotypic analysis using environmental challenges
  2. Combining environmental challenges

GMCIII:

  1. Systemic analysis of compounds and drugs

View results of mutant lines

View the results of mutant mouse lines in the GMC phenomap.

How primary mouse phenotyping leads to novel insights for human health

Mouse phenotyping helps to better understand human diseases. Read more how systemic primary screening of mouse mutants uncovers unexpected new gene functions.

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The GMC Consortium

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