GMC - German Mouse Clinic

GMC

German Mouse Clinic

GMC - German Mouse Clinic

GMC

German Mouse Clinic

07.08.2025

Toxic metabolite reduction: A gene-therapeutic strategy for Glutaric Aciduria Type I

In a collaborative effort within the international CHARLIE consortium, researchers have developed a gene therapy strategy for the rare genetic…

11.07.2025

Role of WSB2 in a new type of neurodevelopmental syndrome

In a recent study published in the European Journal of Human Genetics (2025), clinicians and scientists collaborated to understand the cause of…

15.04.2025

Accelerated aging and telomere shortening induced by Ten1 deficiency in mice

DNA stability and structure need to be preserved during life to ensure proper cellular and organismal functions. End-of-chromosome complexes,…

14.01.2025

Team play of X-linked lncRNAs Crossfirre and Firre regulates autosomal genes in vivo

The lncRNA Crossfirre was identified as an imprinted X-linked gene and is transcribed antisense to the trans-acting lncRNA Firre. The Firre locus…

30.09.2024

Study revealed protective role of Opa1 processing in mitochondrial cardiomyopathy

Four Opa1 isoforms are expressed in mice, which differ in the presence or absence of cleavage sites for Oma1 and for Yme1l. Mutations in the gene OPA1

Phenotype your mouse model

GMC I: 

  1. Systemic, comprehensive phenotyping in 14 different disease areas
  2. Customized primary phenotypic screening in specific areas of interest (e.g. behavior, neurology and neuropathology)

GMC II: 

  1. Hypothesis-driven phenotypic analysis using environmental challenges
  2. Combining environmental challenges

GMCIII:

  1. Systemic analysis of compounds and drugs

How primary mouse phenotyping leads to novel insights for human health

Mouse phenotyping helps to better understand human diseases. The German Mouse Clinic characterizes mouse models for human diseases to understand molecular mechanisms of human disorders and for the development of new therapies. We provide a phenotyping platform for the scientific community, using a broad standardized phenotypic check-up of all clinically relevant organ systems or disease specific test-pipelines. Together with the International Mouse Phenotyping Consortium, we provide our expertise and infrastructure for the primary screening of mouse mutants to uncover unexpected new gene functions. The results are uploaded to our phenomap.

View results of mutant lines

View the results of mutant mouse lines in the GMC phenomap.

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