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GMC - German Mouse Clinic

GMC

German Mouse Clinic

GMC - German Mouse Clinic

GMC

German Mouse Clinic

24.11.2020

Increased estrogen to androgen ratio in mice feminize the male immune system

In a common effort, scientists of the German Mouse Clinic and Turku University examined the immune system of genetically modified mice that develop a...

16.11.2020

New methyltransferase METTL6 and its role in cancer

Methylations are among the most prevalent RNA modifications and multiple METTL proteins have been implicated in different types of cancers. In a...

07.09.2020

Is there an essential physiological role for the oncogenic neuronal inositol-1,4,5-trisphosphate 3-kinase?

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is the neuronal isoform of ITPKs and exhibits both actin bundling and InsP3kinase activity. In...

24.08.2020

METTL5 – a new human RNA methyltransferase that is involved in human diseases

An international team of researchers lead by Helmholtz Zentrum München uncovered the molecular mechanisms that link rRNA methylation to development...

10.03.2020

New link between iron deficiency in pancreatic cells and diabetes

The role for iron in the pathogenesis of diabetes is on debate. While the consequences of excess iron in β-cell function and survival are established,...

Phenotype your mouse model

GMC I: 

  1. Systemic, comprehensive phenotyping in 14 different disease areas
  2. Customized primary phenotypic screening in specific areas of interest (e.g. behavior, neurology and neuropathology)

GMC II: 

  1. Hypothesis-driven phenotypic analysis using environmental challenges
  2. Combining environmental challenges

GMCIII:

  1. Systemic analysis of compounds and drugs

View results of mutant lines

View the results of mutant mouse lines in the GMC phenomap.

How primary mouse phenotyping leads to novel insights for human health

Mouse phenotyping helps to better understand human diseases. Read more how systemic primary screening of mouse mutants uncovers unexpected new gene functions.

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The GMC Consortium

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