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GMC - German Mouse Clinic


German Mouse Clinic

GMC - German Mouse Clinic


German Mouse Clinic


Novel Genes That Influence Bone Mineral Density

Researchers from Helmholtz Zentrum München, together with the International Mouse Phenotyping Consortium (IMPC), have uncovered a large number of...


Increased estrogen to androgen ratio in mice feminize the male immune system

In a common effort, scientists of the German Mouse Clinic and Turku University examined the immune system of genetically modified mice that develop...


New methyltransferase METTL6 and its role in cancer

Methylations are among the most prevalent RNA modifications and multiple METTL proteins have been implicated in different types of cancers. In a...


Is there an essential physiological role for the oncogenic neuronal inositol-1,4,5-trisphosphate 3-kinase?

Inositol-1,4,5-trisphosphate 3-kinase-A (ITPKA) is the neuronal isoform of ITPKs and exhibits both actin bundling and InsP3kinase activity. In...


METTL5 – a new human RNA methyltransferase that is involved in human diseases

An international team of researchers lead by Helmholtz Zentrum München uncovered the molecular mechanisms that link rRNA methylation to development...

Phenotype your mouse model


  1. Systemic, comprehensive phenotyping in 14 different disease areas
  2. Customized primary phenotypic screening in specific areas of interest (e.g. behavior, neurology and neuropathology)


  1. Hypothesis-driven phenotypic analysis using environmental challenges
  2. Combining environmental challenges


  1. Systemic analysis of compounds and drugs

View results of mutant lines

View the results of mutant mouse lines in the GMC phenomap.

How primary mouse phenotyping leads to novel insights for human health

Mouse phenotyping helps to better understand human diseases. Read more how systemic primary screening of mouse mutants uncovers unexpected new gene functions.

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