The goal of the nociception screen is to identify mice with altered pain responses. For the screening pipeline acute thermal sensitivity is measured to assess the integrity of nociceptive pathways. Further nociception testing for hypothesis-driven approaches, i.e. chemical and mechanical as well as changes in nociceptive thresholds after inflammation can be discussed with the expert partner.
Hotplate assay: type and latency until first and second reaction to hotplate within maximum 30 seconds.