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Technologies

Technical Information

Bruker BioSpin multi-purpose MR scanner, equipped with a 9.4 Tesla magnet, optimized gradient coils for great efficiency of scanning processes, and several radiofrequency coils for different applications with different stable nuclei (Hydrogen, Carbon, Fluorine and Phosphorus). A cryogenic radiofrequency coil is also available. The cryogenic coil delivers excellent resolution and up to 2.5 higher signal than standard coils. In addition, it has auxiliary software and special accessories to facilitate investigation in vivo.

Applications

Obesity and Diabetes Research

The MRT technology is being used to study morphological and metabolic changes in the liver in the context of diabetes research. Spectroscopic techniques are used to investigate specific fatty acid deposition in the mouse liver during high fat diet.
Imaging techniques are used for determining volume changes in liver and to visualize modifications in the tissue appearance during the experiment.
This kind of experiment is an example of multiple longitudinal analysis of the same animal that helps learning about the development of diseases.

Coronal slice of a mouse liver: before being fed with high fat diet.
Coronal slice of a mouse liver: after 12 weeks on high fat diet.
Liver spectra: mouse on safflower oil enriched diet. Blue line: before high fat diet. Red line: after 3 weeks on high fat diet. Green line: 6 weeks on high fat diet.

Cardiac Imaging

Cardiac MRI can be performed either synchronizing the acquisition with the cardiac and respiratory cycle or using a retrospective gating method (IntraGate™).

With Cardiac MRI it is possible to analyze fine heart structures, allowing the quantification of heart chambers size, left and right ventricle walls thicknesses in different moments of the cardiac cycle, etc. These analyses are performed in collaboration with the Cardiovascular Screen.

Heart short axis: systole.
Heart short axis: diastole.

Other applications

  • MRI and MRS analysis of kidneys for recognition of fibrotic and cystic kidney phenotype.
  • Brain imaging for structural analysis and evaluation of certain parameters related to the increase of free water content in the brain caused by aging processes.
  • Improvement of techniques to image auditory and vestibular system.

Head

Dr. Markus Kraiger    
Tel. +49 89 3187-3138
Fax +49 89 3187-3500
E-mail

Dr. Helmut Fuchs    
Tel. +49 89 3187-3151
Fax: +49 89 3187-3500
E-mail

Prof. Dr. Martin Hrabé de Angelis    
Tel. +49 89 3187-3302
Fax +49 89 3187-3500
E-mail