Lung function screen (optional)
The goal of the general lung function screen is to evaluate genotype specific differences in respiratory function of anesthetized restrained animals, for lung disease patterns typical for chronic lung diseases e.g. COPD, asthma, and lung fibrosis. Gaining Insight into the genetic background involved in these phenotypes will help to improve our current understanding on genetic traits of lung function development as well as genetically linked pathways for disorders of the lung, and will offer the opportunity for developing new therapeutic or preventive strategies in biomedical research.
Pulmonary function testing of anesthetized restrained animals for clinically relevant parameters (e. g. resistance, dynamic and quasi-static compliance, forced residual capacity, total lung capacity, inspiratory capacity, residual volume, forced expiratory volume at 0.1 s, forced vital capacity, peak expiratory now).