Pipeline C - Memory impairment
- Spontaneous alternation in the Y-maze – spatial working memory
- Social Discrimination test – social recognition memory, olfactory memory
- Object Recognition test – object recognition memory
- IntelliCage – spatial learning and memory, reversal learning, reward learning
- Olfactory discrimination – olfactory learning and function: sensitivity, discriminatory abilities, long-term olfactory memory
- Neurogenesis rate – assessment of adult neurogenesis in brain hippocampus, olfactory bulb and rostral migratory stream using different neurogenesis markers; deficits are related to memory impairments
- Pharmacologic challenge – possibility to validate behavioural alterations by influencing them through application of relevant pharmacological agents, e.g. specific compounds to enhance memory or specific receptor ligands